Biography
Dr Sarah Jenkinson teaches all aspects of the Organic Chemistry course at St Hilda's and several other colleges. She also lectures and co-organises the 1st year Mechanistic Biochemistry course for the Department of Biochemistry.
Dr Sarah Jenkinson's research is focused in the area of carbohydrate chemistry with an emphasis on the synthesis of rare and branched sugars as building blocks for drug development. Specific targets include diabetes and cystic fibrosis drugs as well as anti-cancer agents.
Liu, Z.; Yoshihara, A,; Jenkinson, S. F.; Wormald, M. R.; Kelly, C.; Heap, J. T.; Marqvorsen, M. H. S.; Estévez, R. J.; Fleet, G. W. J.; Nakagawa, S.; Izumori, K.; Nash, R. J.; Kato, A., Hanessian-Hullar Reaction in the Synthesis of Highly Substituted trans-3,4-Dihydroxypyrrolidines: Rhamnulose Iminosugar Mimics Inhibit a-Glucosidase, Tetrahedron, 2020, 76, 130758.
Nash, R. J.; Bartholomew, B.; Penkova, Y. B.; Rotondo, D.; Yamasaka, F.; Stafford, G. P.; Jenkinson, S. F.; Fleet, G. W. J., Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity, ACS Omega 2020, 5, 26, 16263.
Liu, Z.; Jenkinson, S. J.; Yoshihara, A.; Wormald, M. R.; Izumori, K.; Fleet, G. W. J., D-Idose, D-iduronic acid and D-idonic acid from D-glucose via seven carbon sugars, Molecules 2019, 24, 3758.
Martínez, R. F.; Jenkinson, S. F.; Nakagawa, S.; Kato, A.; Wormald, M. R.; Fleet, G. W. J.; Hollinshead, J.; Nash, R. J., Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids, Amino Acids 2019, 51, 991-998.
Kato, A.; Nakagome, I.; Nakagawa, S.; Kinami, K.; Adachi, I.; Jenkinson, S. F.; Désiré, J.; Blériot, Y.; Nash, R. J.; Fleet, G. W. J.; Hirono, S., In Silico Analyses of Essential Interactions of Iminosugars With the Hex a Active Site and Evaluation of Their Pharmacological Chaperone Effects for Tay-Sachs Disease, Org. Biomol. Chem. 2017, 15, 9297-9304.
Glawar, A. F. G.; Martínez, R. F.; Ayers, B. J.; Hollas, M. A.; Ngo, N.; Nakagawa, S.; Kato, A.; Butters, T.D.; Fleet, G. W. J. ; Jenkinson, S. F., Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids, Org. Biomol. Chem. 2016, 14, 10371-10385.
Liu, Z.; Jenkinson, S. F.; Vermaas, T.; Adachi, I.; Wormald, M. R.; Hata, Y.; Kurashima, Y.; Kaji, A.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J., 3-Fluoro-azetidine Carboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar, J. Org. Chem. 2015, 80, 4244–4258.
Ayers, B. J.; Glawar, A. F. G.; Martínez, R. F.; Ngo, N.; Liu, Z.; Fleet, G. W. J.; Butters, T. D.; Nash, R. J.; Yu, C.-Y.; Wormald, M. R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S. F., 9 of 16 Stereoisomeric Polyhydroxylated Proline Amides are Potent β-N-Acetylhexosaminidase Inhibitors, J. Org. Chem. 2014, 79, 3398-3409.
Martínez, R. F.; Liu, Z.; Glawar, A. F. G; Yoshihara, A.; Izumori, K.; Fleet, G. W. J.; Jenkinson, S. F., Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid, Angew. Chem. Int. Edit. 2014, 53, 1160-1162; Kurz und Knapp: L-Glucose und L-Gluconsaure von D-Glucose, Angew. Chem. 2014, 126, 1179-1182.
Jenkinson, S. F., Best, D., Saville, A. W., Mui, J., Martínez, R. F., Nakagawa, S., Kunimatsu, T., Alonzi, D. S., Butters, T. D., Norez, C., Becq, F., Blériot, Y., Wilson, F. X., Weymouth-Wilson, A. C., Kato, A., Fleet, G. W. J., C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP and isoDAB – L-isoDMDP Compared to Miglitol and Miglustat, J. Org. Chem. 2013, 78, 7380-7397.
Positions
- Lecturer in Chemistry
Subjects
- Chemistry
