Biography
Dr Philippa Hulley was Senior Lecturer (University of Stellenbosch Faculty of Health Sciences) from 1996-2003 and joined the newly established Botnar Research Centre (University of Oxford) in 2003. Dr Hulley teaches options in the Cell and Systems major across 4 years of the Biomedical Sciences course and 3 years of Preclinical Medicine. She is Organizing Tutor for Biomedical Sciences at St Hilda’s.
Dr Philippa Hulley studies drug mechanisms and side effects in musculoskeletal tissues. Her current work focuses on development of human bone organoids for use in drug and disease modelling. Translational projects with industry and clinicians are a special interest. Dr Hulley leads a research group investigating cell signalling in bone and joint degeneration and regeneration and supervises laboratory-based DPhil, MD and MSc research students.
Publications
Perry TA, Deng Y, Hulley PA, Maciewicz RA, Mitchelmore J, Larsson S, Gogain J, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Bondi L, Kapoor M, Lohmander LS, Welting TJ, Walsh DA, Valdes AM, Jostins-Dean L, Watt FE, Tom BDM, Vincent TL; STEpUP OA Consortium. Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum. Nat Commun. 2026 Jun 2;17(1):4721. doi: 10.1038/s41467-026-71632-4.
Cohen CJ, Mimpen JY, Kurjan A, Paul C, Sharma S, Ramos-Mucci L, Ikwuanusi CT, Aksu AC, Boakye Serebour T, Nikolic M, Rue-Albrecht K, Gibbons C, Whitwell D, Cosker T, Gwilym S, Siddiqi A, Rajasekaran RB, Branford-White H, Cribbs AP, Hulley PA, Sims D, Baldwin MJ, Snelling SJB. Fibroblast specialization across microanatomy in a single-cell atlas of human Achilles tendon. Am J Physiol Cell Physiol. 2026 May 1;330(5):C1460-C1473. doi: 10.1152/ajpcell.00838.2025.
Mimpen JY, Baldwin MJ, Paul C, Ramos-Mucci L, Kurjan A, Cohen CJ, Sharma S, Chevalier Florquin MSN, Hulley PA, McMaster J, Titchener A, Martin A, Costa ML, Gwilym SE, Cribbs AP, Snelling SJB. Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution. J Physiol. 2025 Aug;603(16):4535-4554. doi: 10.1113/JP287812.
Deng Y, Perry TA, Hulley P, Maciewicz RA, Mitchelmore J, Perry D, Larsson S, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Marsden B, Tom BDM, Bondi L, Kapoor M, Batchelor V, Mackay-Alderson J, Kumar V, Lohmander LS, Welting TJ, Walsh DA, Valdes AM; STEpUP OA Consortium; Vincent TL, Watt FE, Jostins-Dean L. Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium. PLoS One. 2024 Nov 18;19(11):e0309677. doi: 10.1371/journal.pone.0309677.
Mimpen JY, Ramos-Mucci L, Paul C, Kurjan A, Hulley PA, Ikwuanusi CT, Cohen CJ, Gwilym SE, Baldwin MJ, Cribbs AP, Snelling SJB. Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendon. FASEB J. 2024 May 31;38(10):e23629. doi: 10.1096/fj.202300601RRR.
Knowles HJ, Vasilyeva A, Sheth M, Pattinson O, May J, Rumney RMH, Hulley PA, Richards DB, Carugo D, Evans ND, Stride E. Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation. Biomaterials. 2024 Mar;305:122448. doi: 10.1016/j.biomaterials.2023.122448.
Knowles HJ, Chanalaris A, Koutsikouni A, Cribbs AP, Grover LM, Hulley PA. Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin. Front Endocrinol (Lausanne). 2023 May 8;14:1167734. doi: 10.3389/fendo.2023.1167734.
See Dr Hulley's departmental web page for her full list of publications.
Positions
- Tutorial Fellow in Biomedical Sciences
- Associate Professor in Musculoskeletal Sciences, Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences
Subjects
- Biomedical Sciences
