Biography
My research focuses on investigating the phenotype and function of T cells from patients with Ankylosing Spondylitis and other inflammatory arthritidies. I am using cellular techniques to examine Th17 cells and identify factors predicting a positive outcome to treatment, thereby allowing treatments to be tailored to individuals. I joined Paul Bownness's group in 2009 as a research assistant and undertook my DPhil at the Weatherall Institute of Molecular Medicine.
Prior to joining the University of Oxford I trained as a Clinical Scientist in Immunology at Southampton General Hospital and then was involved in clinical trials monitoring at Oxford BioMedic.
Simone D, Penkava F, Ridley A, Sansom S, Al-Mossawi MH, Bowness P. (2021). Single cell analysis of spondylarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fate. Commun Biol. 4(1):1395
Shi H, Chen L, Ridley A, Zaarour N, Brouugh I, Caucci C, Smith JE, Bowness P. (2020). GM-CSF primes pro inflammatory monocyte responses in ankylosing spondylitis. Front immunology. 16(11): 1520
Hammitzsch A, Chen L, de Wit J, Al-Mossawi MH, Ridley A, Sekine T, Simone D, Doig K, Skapenko A, Bowness P. (2018). Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases. Sci Rep. 8(1):15645
Al-Mossawi MH, Chen L, Fang H, Ridley A, de Wit J, Yager N, Hammitzsch A, Pulyakhina I, Fairfax BP, Simone D, Yi Y, Bandyopadhyay S, Doig K, Gundle R, Kendrick B, Powrie F, Knight JC, Bowness P. (2017). Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis. Nat Commun. 8(1):1510.
Ridley A., Hatano H., Wong-Baeza I., Shaw J., Matthews KK., Al-Mossawi H., Ladell K., Price DA., Bowness P. and Kollnberger S. (2016). Activation-induced KIR3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in Spondyloarthritis. Arthritis Rheumatol. 68(4): 901-14
Wong-Baeza, I., Ridley, A., Shaw, J., Hatano, H., Rysnik, O., McHugh, K., Piper, C., Brackenbridge, S., Fernandes, R., Chan, A., Bowness, P., and Kollnberger, S. (2013). "KIR3DL2 Binds to HLA-B27 Dimers and Free H Chains More Strongly than Other HLA Class I and Promotes the Expansion of T Cells in Ankylosing Spondylitis." J Immunol. 190(7): 3216-24
Al-Mossawi, M. H., Ridley, A. Kiedel S, and Bowness P.(2013). "The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis." Curr Opin Rheumatol 25(4): 434-9.
Bowness, P., Ridley, A., Shaw, J., Chan, A. T., Wong-Baeza, I., Fleming, M., Cummings, F., McMichael A. and Kollnberger, S. (2011). "Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis." J Immunol 186(4): 2672-80.
Positions
- Lecturer in Medicine (Pathology)
Subjects
- Pre-Clinical Medicine