Dr Sarah Snelling

MBiochem DPhil (Oxf)

Profile

Dr Sarah Snelling is an Associate Professor in the Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science.

She studied Molecular and Cellular Biochemistry at St Catherine's College Oxford, and has a DPhil in Musculoskeletal Science from Oxford University.

Research

Dr Snelling's work focusses on how the responses of endogenous cells to implanted biomaterials can modulate inflammation and improve repair of damaged soft tissues like tendon and cartilage. To better understand the environment in which these biomaterials are implanted, Dr Snelling also investigates the activity of key mediators of inflammation and fibrosis in osteoarthritis and tendon disease.

Publications

Selected Publications

  • Baldwin M., Snelling S., Dakin S., Carr A (2018). Augmenting endogenous repair of soft tissues with nanofibre scaffolds. Journal of the Royal Society, Interface, 15
  • Mosca MJ, Rashid MS, Snelling SJ, Kirtley S, Carr AJ, Dakin SG (2018). Trends in the theory that inflammation plays a causal role in tendinopathy: a systematic review and quantitative analysis of published reviews.  BMJ open sport & exercise medicine, 4
  • Morita W, Dakin SG, Snelling SJB, Carr AJ (2017). Cytokines in tendon disease: A Systematic Review. Bone and Joint Research. 6:656-664.
  • Snelling SJ, S Bas, GJ Puskas, SG Dakin, D Suva, A Finckh, C Gabay, P Hoffmeyer, AJ Carr, A Lübbeke (2017). Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. PLOSOne. 11;12(4):e0175109
  • Kendal AR, Snelling SJ, Dakin SG, Stace E, Mouthuy P, Carr AJ (2017). Resorbable electrospun polydioxanone fibres modify the behaviour of cells from both healthy and diseased human tendons. Eur Cell Mater. 20;33:169-182
  • Rowland DC, Aquilina T, Klein A, Hakimi O, Mouthuy P, Carr AJ, Snelling SJ (2016). A comparative evaluation of the effect of polymer chemistry and fiber orientation on mesenchymal stem cell differentiation. J Biomed Mater Res A. 104(11):2843-53
  • H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.Yapp C, Carr AJ, Price A, Oppermann U, Snelling SJ. Arthritis Res Ther. 2016;18(1):158
  • Snelling SJ, Davidson RK, Swingler TE, Le LT, Barter MJ, Culley KL, Price A, Carr AJ, Clark IM (2016). Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role. Osteoarthritis and Cartilage. 24(5):883-91