Dr Muhammad Sohail

DPhil, MPhil, MSc


Riedemann J, Sohail M, Macaulay VM (2007) Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells. Biochemical and Biophysical Research Communications 355, 700-706.

Riedemann J, Takiguchi M, Sohail M, Macaulay VM (2007) The EGF receptor interacts with the type 1 IGF receptor and regulates its stability. Biochemical and Biophysical Research Communications 355, 707-714. G Doran and M Sohail (2006) Systematic analysis of the role of target site accessibility in the activity of DNA enzymes. Journal of RNAi and Gene Silencing 2, 161-214.

MA Rafiq, M Faiyaz-ul-Haque, M Amin-ud-Din, S Malik, M Sohail, M Anwar, Sayed-ul-Haque, AD Paterson, L-C Tsui, W Ahmad (2005) A novel locus of Ectodermal Dysplasia maps to Chromosome 10q24.32-q25.1. Journal of Investigative Dermatology 124, 338-342.

M Sohail, G Doran, S Kang, S Akhtar and Edwin M Southern (2005) Structural re-arrangements in RNA on the binding of an antisense oligonucleotide: Implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents. Journal of Drug Targeting 13, 66-71.

M Sohail and G Doran (2005) Enzymatic production of small interfering RNAs: In K Appasani (Ed), RNA Interference: From Basic Science to Drug Development, Cambridge University Press, Cambridge, England.

M Hussain, M Schepinov, M Sohail, EM Southern and S Akhtar (2004) A novel anionic dendrimer for the delivery of oligonucleotides. Journal of Controlled Release 99, 135-155.

AJ Hollins, SP Fox, IR Gilmore, M Sohail and S Akhtar (2004) Design and exogenous delivery of small interfering RNAs for post-transcriptional gene silencing. Journal of Drug Targeting 12, 315-340.

M Sohail (Editor) (2004) Gene Silencing by RNA Interference: Technology and Applications, CRC Press, Philadelphia, USA.

G Doran and M Sohail (2004) Production of siRNAs with the application of deoxyribozymes: In, M Sohail (Ed), Gene Silencing by RNA Interference: Technology and Applications, CRC Press, Philadelphia, USA.

VM Macaulay and M Sohail (2004) Oligonucleotide scanning arrays in the design of small interfering RNAs: In, M Sohail (Ed), Gene Silencing by RNA Interference: Technology and Applications, CRC Press, Philadelphia, USA.

G Beale, AJ Hollins, M Benboubetra, M Sohail, SP Fox, I Benter, and S Akhtar (2003) Gene silencing nucleic acids designed by scanning arrays: Anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system. Journal of Drug Targeting 11, 449-456.

M Sohail (2003) SiRNA selection and co-operativity. Patent application. AK Petch, M Sohail, MD Hughes, G Beale, I Benter, J Darling, EM Southern and S Akhtar (2003) Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with array-designed antisense oligonucleotides. Biochemical Pharmacology 66, 819-830.

MA Rafique, M Ansar, SM Jamal, M Sohail, MF ul Haque, S ul Haque, SM Leal, W Ahmad (2003) A novel locus for localized inherited Alopecia mapped to human chromosome 18q21.1. European Journal of Human Genetics 11, 623-628.

EA Bohula*, AJ Salisbury*, M Sohail*, MP Playford, J Riedemann, EM Southern and VM Macaulay (*Joint first authors) (2003) The efficacy of small interfering RNAs targeting the type 1 IGF receptor is influenced by secondary structure in the IGF1R transcript. Journal of Biological Chemistry 278, 15991-15997.

M Sohail, G Doran, J Riedemann, V Macaulay, EM Southern (2003) Production of siRNAs by in vitro transcription and deoxyribozyme digestion. Nucleic Acids Research 31, e38.

M Ansar, MA ud Din, M Arshad, M Sohail, MF ul Haque, S ul Haque, W Ahmad, SM Leal (2003) A novel autosomal recessive non-syndromic deafness locus (DFNB35) maps to 14q24.1 – 14q24.3 in large consanguineous kindred from Pakistan. European Journal of Human Genetics 11, 77-80.

M Sohail (2002) Methods of producing RNAs of defined length and sequence. Patent application.

VM Macaulay and M Sohail (2002) Molecular targeting of IGF-1 receptor. Patent application.

VM Macaulay and M Sohail (2002) Methods of selecting targets for gene silencing by RNA interference. Patent application.

M Sohail and EM Southern (2002) Oligonucleotide scanning arrays: Application to high-throughput screening for effective antisense reagents and the study of nucleic acid interactions. In: JD Hoheisel (Ed.) Advances in Biochemical Engineering/Biotechnology (Special volume on Chip Technology), Springer-Verlag, Heidelberg, Vol 77, 43-56.

M Sohail (2001) Antisense technology: inaccessibility and non-specificity. Drug Discovery Today 6, 1260-1261. H Hochegger, A Klotzbücher, J Kirk, M Howell, R Guellec, K Fletcher, T Duncan, M Sohail and T Hunt (2001) New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation. Development 128, 3795-3807.

M Sohail, H Hochegger, A Klotzbücher, R Guellec, T Hunt and EM Southern (2001) Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. Nucleic Acids Research 29, 2041-2051.

M Sohail and EM Southern (2001) Using oligonucleotide scanning arrays to find effective antisense reagents. In: JB Rampal (Ed.) Methods in Molecular Biology: Oligonucleotide Arrays-Methods and Protocols, Humana Press, Totowa, NJ, Vol. 170, 181-199.

NJ Housby and M Sohail (2000) When is a chip not a chip? Trends in Biotechnology 18, 439-440.

M Sohail and EM Southern (2000) Selecting optimal antisense oligonucleotides. Advanced Drug Delivery Reviews 44, 23-34.

M Sohail, and EM Southern (2000) Antisense arrays. Molecular Cell Biology Research Communications 3, 67-72.

M Sohail and EM Southern (2000) Hybridisation of antisense reagents to RNA. Current Opinion in Molecular Therapeutics 2, 264-271.

W Ahmad, M de Fusco, MF ul Haque, P Aridon, T Sarno, M Sohail, S ul Haque, M Ahmad, A Ballabio, B Franco and G Casari (1999) Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity. European Journal of Human Genetics 7, 828-832.

JK Elder, MG Johnson, N Milner, K Mir, M Sohail and EM Southern (1999) Antisense Oligonucleotide Scanning Arrays. In: M Schena (Ed.) DNA Microarrays: A Practical Approach, IRL Press, Oxford, UK, 77-98.

M Sohail, S Akhtar and EM Southern (1999) The folding of large RNAs studied by hybridisation to arrays of complementary oligonucleotides. RNA 5, 646-655.

M Sohail (1998) A simple and rapid method for preparing genomic DNA from gram-positive bacteria. Molecular Biotechnology 10, 191-193.

M Sohail and K Sultana (1998) Antibiotic susceptibilities and plasmid DNA analyses of Shigella flexneri isolates from children with diarrhoea in Islamabad, Pakistan. Journal of Antimicrobial Chemotherapy 42, 838-839.

M Sohail and KGH Dyke (1996) Suppression of the thermo-sensitive replication of the derivative plasmid of pI9789::Tn552 in Staphylococcus aureus may involve integration of the plasmid into the host chromosome. FEMS Microbiology Letters 136, 129-136.

M Sohail and KGH Dyke (1995) Site for co-integration of large staphylococcal plasmids. Gene 162, 63-68.

M Sohail, M Oldridge and KGH Dyke (1995) Interaction of the chromosomal Tn551 with two thermo-sensitive derivatives, pS1 and p-D, of the plasmid pI9789 in Staphylococcus aureus. FEMS Microbiology Letters 127, 165-170.