Lecturer and Director of Studies in Biochemistry
Dr Mary Board read Biochemistry at Balliol College and received a doctorate on the subject of energy metabolism in tumour cells. She has taught widely and has current affiliation with the Royal College of Obstetricians and Gynaecologists (as an invited lecturer) as well as with St Hilda's College (as lecturer and director of studies in biochemistry). She is Metabolism module leader for the school of Graduate Entry Medicine.
Dr Board’s research interests centre around control of metabolic pathways. She has pursued a research career in the area of metabolic control in diabetes, obesity and cancer and is currently extending these studies to the area of stem cells. Current projects centre around the control of fuel metabolism in tumour cells and in stem cells in both their pre-differentiated and differentiating states.
Smith, H., DeSouza, D., Tull, D., McConville, M. Pellagatti, A., Boultwood, J., Board, M. and Callaghan, R. (2021) The utilisation of glutamine and glucose by a 3-D tumour model trapped in quiescence Int. J. Biochem and Cell Biol. 133, 105935.
Board, M. (2021) Starvation rations : the therapeutic potential of ketone bodies for stem cell function in Human Mesenchymal Stem Cells Stem Cells : Clinical and Laboratory Research (Ed. Khan, M.), Nova Medicine and Health, New York p101-129.
Dimitriadis, G.D., Maratou E., Kountouri, A., Board, M. and Lambadiari, V. Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach (2021) Nutrients 13, 159. https://doi.org/10.3390/nu13010159
Callaghan, R. and Board, M. UCP2 - Taking the heat out of P-glycoprotein? Cancer Drug Resistance 2020 (3) DOI: 10.20517/cdr.2020.105
Faulkner, A. R. M., Lynam, E., Purcell, R., Jones, C., Lopez, C., Board, M., Wagner, K., Wagner, N., Carr, C. & Wheeler-Jones, C. (2020) Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A In : Scientific Reports. 10, 1, 15, 7849.
Board, M., Lopez, C., van den Bos, C., Callaghan, R., Clarke, K. and Carr, C. (2017) Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species. Int. J. Biochem Cell Biol. 88, 75-83
"Functional Biochemistry in Health and Disease", Newsholme and Leech (edited by Board (John Wiley), 2010.
"Carbohydrate, Fat and Protein Metabolism" , Board, M. in Revision Guide for Membership of Royal College of Obstetricians and Gynaecologists, RCOG Press, first edition published 2010. Second edition, MRCOG Part One: Your Essential Revision Guide, published 2016, CUP.
Numerous papers in Scientific Journals, including:
1) Board, M., Lopez, C., van den Bos, C., Callaghan, R., Clarke, K. and Carr, C. "Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species." Int. J. Biochem Cell Biol. 2017 88, 75-83; investigating substrate choice and utilisation in human stem cells.
2) Smith, H., Board, M., Pellagatti, A., Turley, H, Boultwood, J., and Callaghan, R. "The effects of severe hypoxia on glycolytic flux and enzyme activity in a model of solid tumours." J.Cell.Biochem. 2016 1999, 1-12; looking at metabolism throughout diferent zones of solid tumours.
3) Board, Colquhoun and Newsholme "High Km glucose-phosphorylating (glucokinase) activities in a range of tumour cell-lines and inhibition of rates of tumor growth by the specific enzyme inhibitor, mannoheptulose" Cancer Research, 1995, vol. 55 (15), pages 3278-3285. This describes the action of a patented tumour inhibitor.
