Dr Maike D Glitsch

PhD, MSc equivalent, UL in Biomedical Sciences and Muriel Tomlinson Fellow in Preclinical Medicine

Profile

Tutorial Fellow in Medicine

Maike Glitsch read Biological Sciences at Giessen (prelims) and Goettingen (Diplom, PhD). She became interested in the regulation of synaptic transmission when carrying out research for her Diploma thesis (Masters thesis equivalent) in Professor Erwin Neher’s Department at the Max Planck Institute for Biophysical Chemistry and followed this up with her PhD, working in the same department under Drs Alain Marty and Isabel Llano, looking at the regulation of inhibitory synaptic transmission in brain slices using electrophysiology and fluorescence Ca2+ imaging.

Following her PhD, Dr Glitsch moved to the then University Laboratories of Physiology (today: Department of Physiology, Anatomy and Genetics) on an HFSP Long Term Fellowship to work in the laboratory of Professor Julian Jack. She gained her independence with a Dorothy Hodgkin Royal Society Fellowship, was a Junior Research Fellow at St Anne’s College and became Director of Studies in Physiology (the old Biomedical Sciences Course) at St Catherine’s College.

In 2009, Dr Glitsch was appointed University Lecturer / Associate Professor in Biomedical Sciences at the Department of Physiology, Anatomy and Genetics and Muriel Tomlinson Tutorial Fellow in Medicine at St Hilda’s College, where she is Senior Subject and Organising Tutor in Medicine. She is a Reviewing Editor for the Journal of Physiology and a Fellow of the Royal Society of Biology. Within the Division, Dr Glitsch serves on the Educational Policy and Standards Committee (among others) and is a member of the Oxion Research Cluster. In 2017, she was appointed Vice-Director of the Centre for Integrative Neuroscience, which was officially opened in 2018. 

Dr Glitsch is co-organiser of the St Hilda’s “Brain and Mind – from concrete to abstract” series of interdisciplinary workshops that looks at brain-related issues from the point of view of neuroscience, psychology, clinical medicine and philosophy. These workshops take place in St Hilda’s every term and cover topics as diverse as schizophrenia, music, and bilingualism. They are aimed at a broad audience composed of fellow academics, students and the general public.

 

Teaching

Dr Glitsch teaches at both departmental and college level. She provides lectures for the preclinical medical and biomedical sciences course (1st, 2nd and 3rd year) and for the MSc course in Neuroscience; she also provides introductory neuroscience lectures for the Human Sciences Course. At college, she gives tutorials to all preclinical year groups, teaching principles of excitable cells and membranes in 1st year, neuroscience in 2nd year and specialist teaching in Neuroscience and Cell Physiology and Pharmacology as well as general methods teaching in 3rd year. In 2012, Dr Glitsch was awarded an Excellence in Teaching Award from the Medical Division and in 2015 the Outstanding Tutor Award in the Medical Division from the Oxford University Student Union for her teaching (shortlisted again in 2017).

Research

Dr Glitsch’s research interest revolves around how cells in the mammalian brain communicate with each other, and how this communication is altered in the diseased state. She is interested in signalling cascades involving G protein coupled receptors and ion channels, with a particular emphasis on proton-sensing receptors. Increases in extracellular proton concentration occur under physiological conditions in the brain and also accompany virtually all brain pathologies. Hence, it is important to understand how changes in proton concentrations affect brain cells. Her laboratory employs electrophysiology, fluorescence Ca2+ and H+ imaging, molecular biology and cell function assays to understand how cell communication is shaped by different receptors under distinct conditions.

Publications

Glitsch MD (2019) Mechano- and pH-sensing convergence on Ca2+-mobilising proteins – A recipe for cancer? Cell Calcium, 80:38-45

Wei WC, Bianchi F, Wang YK, Tang MJ, Ye H, Glitsch MD (2018) Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68). Curr Biol, 28:3815-23.e4

Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, J Glitsch MD (2017) Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells. J Physiol, 595:5525-44

Glitsch MD (2018) Gordon Research Conference on Ca2+ Signalling 2017 Editorial. J Physiol, 596:2661-2

Wei WC, Jacobs B, Becker EB, Glitsch MD. (2015 )Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H. Proc Natl Acad Sci U S A. 112(34):10738-43. doi: 10.1073/pnas.1506085112.

Langfelder A, Okonji E, Deca D, Wei WC, Glitsch MD. (2015) Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia. Cell Calcium 57(4):247-56. doi: 10.1016/j.ceca.2015.01.004.

Glitsch M D. Activation of native TRPC3 cation channels by phospholipase, D. FASEB J. 2010;24(1):318-25; PMID: 19741172

Clark RH, McTaggart JS, Webster R, Mannikko R, Iberl M, Sim XL, Rorsman P, Glitsch M, Beeson D, Ashcroft FM. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science. 2010;329(5990):458-61; PMID: 20595581

Glitsch M. Protons and Ca2+: ionic allies in tumor progression? Physiology (Bethesda). 2011;26(4):252-65; PMID: 21841073

Becker EB, Oliver P, Glitsch MD, Banks GT, Achilli F, Hardy A, Nolan PM, Fisher EMC, Davies KE. A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. PNAS 2009 106(16):6706-6711; PMID: 19351902

Huang WC, Swietach P, Vaughan-Jones RD, Glitsch MD. Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells. Cell Calcium 2009 45(5): 391-399; PMID: 19249096

Huang WC, Swietach P, Vaughan-Jones R, Ansorge O, Glitsch MD. Extracellular acidification elicits spatially and temporally distinct Ca2+ signals. Current Biology 2008 18:781-785; PMID: 18485712

Glitsch MD. Calcium influx through NMDA receptors triggers GABA release at interneuron - Purkinje cell synapse in rat cerebellum. Neuroscience 2008 151(2):403409; PMID: 18055124

Glitsch MD. Spontaneous neurotransmitter release and Ca2+ - how spontaneous is spontaneous release? Cell Calcium 2008 43(1):9-15; PMID: 17382386

Huang WC, Young J, Glitsch MD. Changes in TRPC channel expression during postnatal development of cerebellar neurons. Cell Calcium. 2007 42(1):1-10; PMID: 17141310

Glitsch MD. Selective inhibition of spontaneous but not Ca2+-dependent release machinery by presynaptic group II mGluRs in rat cerebellar slices. J Neurophysiol. 2006 96:86-96; PMID: 16611839

Glitsch MD, Bakowski D, Parekh AB. Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake. EMBO J. 2002 21(24):6744-54; PMID: 12485995

Glitsch MD, Bakowski D, Parekh AB. Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells. J Physiol. 2002 539(Pt 1):93-106; PMID: 11850504

Glitsch MD, Jack JJ. Evidence that glutamate acting on presynaptic type-II
metabotropic glutamate receptors alone does not fully account for the phenomenon of depolarisation-induced suppression of inhibition in cerebellar Purkinje cells. Pflugers Arch. 2001 442(3):404-8; PMID: 11484772

Bakowski D, Glitsch MD, Parekh AB. An examination of the secretion-like coupling model for the activation of the v release-activated Ca2+ current I(CRAC) in RBL-1 cells. J Physiol. 2001 532(Pt 1):55-71; PMID: 11283225

Glitsch M, Parra P, Llano I. The retrograde inhibition of IPSCs in rat cerebellar Purkinje cells is highly sensitive to intracellular Ca2+. Eur J Neurosci. 2000 12(3):987-93; PMID: 10762329

Glitsch MD, Parekh AB. Ca2+ store dynamics determines the pattern of activation of the store-operated Ca2+ current I(CRAC) in response to InsP3 in rat basophilic leukaemia cells. J Physiol. 2000 523 Pt 2:283-90; PMID: 10699074

Glitsch M, Marty A. Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons. J Neurosci. 1999 19(2):511-9; PMID: 9880571

Glitsch M, Llano I, Marty A. Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum. J Physiol. 1996 497 (Pt 2):531-7; PMID: 8961193

Marty A, Glitsch M, Kondo S, Llano I. Cyclic AMP-regulated GABA release at inhibitory synapses in rat cerebellar slices. J Physiol Paris. 1996 90(5-6):327-8; PMID: 9089503

Glitsch M, Wischmeyer E, Karschin A. Functional characterization of two 5-HT3 receptor splice variants isolated from a mouse hippocampal cell line. Pflugers Arch. 1996 432(1):134-43; PMID: 8662278