Dr Anna Ridley

BSc Southampton; MSc Lond; DPhil Oxf

Profile

My research focuses on investigating the phenotype and function of T cells from patients with Ankylosing Spondylitis and other inflammatory arthritidies. I am using cellular techniques to examine Th17 cells and identify factors predicting a positive outcome to treatment, thereby allowing treatments to be tailored to individuals. I joined Paul Bownness's group in 2009 as a research assistant and undertook my DPhil at the Weatherall Institute of Molecular Medicine.

Prior to joining the University of Oxford I trained as a Clinical Scientist in Immunology at Southampton General Hospital and then was involved in clinical trials monitoring at Oxford BioMedic.

Publications

Ridley A., Hatano H., Wong-Baeza I., Shaw J., Matthews KK., Al-Mossawi H., Ladell K., Price DA., Bowness P. and Kollnberger S. (2016). Activation-induced KIR3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in Spondyloarthritis. Arthritis Rheumatol. 68(4): 901-14

Roberts A., Vecellio M., Chen L., Ridley A., Cortes A., Knight J., Bowness P., Cohen C., and Wordsworth P. (2016). An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation. Ann Rheum Dis. (accepted for publication)

Chen L., Ridley A., Hammitzsch A., Al-Mossawi MH., Bunting H,, Georgiadis D., Chan A., Kollnberger S. and Bowness P. (2016). Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses i ankylosing spondylitis. Ann Rheum Dis. 75(5): 916-23

Wong-Baeza, I., Ridley, A., Shaw, J., Hatano, H., Rysnik, O., McHugh, K., Piper, C., Brackenbridge, S., Fernandes, R., Chan, A., Bowness, P., and Kollnberger, S. (2013). "KIR3DL2 Binds to HLA-B27 Dimers and Free H Chains More Strongly than Other HLA Class I and Promotes the Expansion of T Cells in Ankylosing Spondylitis." J Immunol. 190(7): 3216-24

Al-Mossawi, M. H., Ridley, A. et al. (2013). "The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis." Curr Opin Rheumatol 25(4): 434-9.

Giles, J., Shaw J, Piper C., Wong-Baeza I., McHugh K., Ridley A., Li D., Lenart I., Antoniou A.N., DiGleria K., Kuroki K., Manenaka K., Bowness P., and Kollnberger S. (2012). "HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class I." J Immunol 188(12): 6184-93.

Payeli, P., Kollnberger S.K., Osiris Marroquin, B., Thiel, M., McHugh, K., Giles, J., Shaw, J., Kleber, S., Ridley, A., Wong-Baeza, I., Keidel, S., Kuroki, K., Maenaka, K., Wadle, A., Renner, C. and Bowness, P. (2012). "Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondyloarthritis." Arthritis Rheum. 64(10): 3139-49.

Bowness, P., Ridley, A., Shaw, J., Chan, A. T., Wong-Baeza, I., Fleming, M., Cummings, F., McMichael A. and Kollnberger, S. (2011). "Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis." J Immunol 186(4): 2672-80.