Dr Yvonne Couch

BSc (Hons) Manchester, MSc (Oxon), DPhil (Oxon)

Research

Junior Research Fellow in Medicine

My primary research field is neuroimmunology, specifically how the brain communicates injury or illness to the systemic immune system, and vice-versa. I am currently studying how injury signals might escape the brain after a stroke, with a particular focus on extracellular vesicles (EVs). EVs are small fragments of cell membrane, shed from cells all the time, and thought to be a novel mechanism of cell to cell communication. My aim is to study whether these EVs contribute to inflammation within the CNS after a stroke, but also whether they contribute to the injury signal that activates the systemic immune system.

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications

Selected publications

  1. Sutherland B.A., Neuhaus A.A., Couch Y. et al. The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke. (JCBFM, 2015)
  2. Couch Y. et al. A model of post-infection fatigue is associated with increased TNF and 5-HT2A receptor expression in mice. PLoS ONE (2015).
  3. Parsons M.J., Brancaccio M., Sethi S., Maywood E.S., Satija R., Edwards J., Jagannath A., Couch Y. et al. The regulatory factor Zfhx3 determines circadian function in the SCN via a novel circadian transcriptional axis. Cell (2015) 162(3):607-21
  4. Sauvignac H.M., Couch Y.  Prebiotic normalizes lipopolysaccharide (LPS)-induced sickness behaviour, anxiety and pro-inflammatory responses in mice. Brain, Behav. and Immun. (2015)
  5. Clausen B.H., Degn M., Couch Y. et al. Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia. J.Neuroinflammation (2014) 11(1):203
  6. Couch Y. et al.  Viral pre-challenge increases central nervous system inflammation after intracranial interleukin-1β injection J.Neuroinflammation (2014) 11:178
  7. Anthony D.C. and Couch Y.: The systemic response to CNS injury. Exp. Neurol. (2014) 258:105-111

Jagannath A., Butler R., Godinho S.H., Couch Y. et al. Negative feedback by the inducible repressor SIK1 regulates light input to the circadian clock Cell (2013) 154(5):1100-11

  1. Brambilla R., Couch Y., Lambertsen K.L: The effect of stroke on immune function. Mol.Cell.Neuro. (2013) 53:26-33

Couch Y. et al. Systemic inflammation alters central 5-HT function as determined by pharmacological MRI. Neuroimage (2013) 15;75:177-86

  1. Couch Y. et al. Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia. Brain Behav Immun. (2013) 29:136-46.